Yes, I have the same issue. I have a MacBook Air and I get the error "We could not activate your DIRECTV GenieGO." There is also a numerical error code in the lower right hand corner, right next to the "System info" link of 'GenieGO/102'.
I am able to get it to work on my wife's Air. The only difference is hers is the smaller Air; we're both on Mavericks and all software is up to date. It also works on my old Dell laptop running Vista, my Galaxy S3 and my wife's iPhone. It's super annoying.